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This campaign ended on Thursday, Mar. 6, 2014

The rise of antibiotic resistant bacteria is a worldwide problem with no immediate solution. Multiple drug resistant "superbugs" cause approximately 2 million infections annually and at least 20,000 people die each year. One of the most widespread "superbugs" is methicillin-resistant Staphylococcus aureus, or MRSA for short, that causes a multitude of infections, including pneumonia, skin infections, and implant infections. To make matters worse, S. aureus can form biofilms that grow on surfaces and are virtually impossible to treat.  Our group has developed new molecules that kill MRSA in cell culture and we want to test them against MRSA biofilms.  Our goal is to raise $5,000 to perform these tests against MRSA biofilms.  These experiments will provide the critical data we need to secure long term funding for this project and seed collaborations with other MRSA researchers as we work to develop new MRSA antibiotics. 

The Problem
 
One of the most common antibiotic resistant pathogens is S. aureus and it is estimated that 25 - 30% of the population is colonized with MRSA. The bacteria is spread by contact or through open wounds and is frequently spread amongst athletes, who share common training equipment, and amongst nursing home patients. This form of community acquired MRSA has genetic mutations that enable it to degrade entire classes of antibiotics.  However, MRSA can also increase its antibiotic resistance when it attaches to surfaces and covers itself with a protective layer of protein and DNA called a biofilm. This is shown in the image below of normal S. aureus cells and those within a biofilm.
This barrier prevents antibiotics from reaching the bacteria underneath and bacteria in the biofilm can be up to a 1000 times more antibiotic resistant. These persistent infections are almost impossible to cure and are a major problem for medical devices, such as catheters or joint implants. For example, when a joint implant develops a S. aureus biofilm, often the only treatment is removal of the joint.

Our solution
Our research group is working to develop new antibiotics that are effective treatments for superbugs. We have developed a new antibiotic discovery technology and have used it to make new compounds that kill antibiotic resistant MRSA. Our system discovers molecules that target the surface of the bacteria which should produce antibiotics that are difficult to develop resistance to. Another unique property of our molecules is that they kill both rapidly growing and slow growing S. aureus, which is different than most antibiotics which target rapidly growing bacteria. We believe that because our molecules can kill slow growing S. aureus that they could also be active against slow growing bacteria in biofilms. 




Get Involved

1. Support our project!
Our goal is to raise $5,000 to advance the development of these compounds for the treatment of MRSA biofilms. These funds will be used to generate new data and make new connections in the field that will help us turn this seed funding into long term project funding. This seed funding is critical as we work to advance our compounds that work at the lab bench into new antibiotics that work at the hospital bedside.
 

2. Wash your hands!

One of the most simple and effective ways you can help is to wash your hands.  Hand washing with soap and water kills bacteria and helps stops the spread of antibiotic resistant bacteria.

3. Learn more


Antibiotic Crisis
http://www.pbs.org/newshour/rundown/2013/10/frontline-asks-has-the-age-of-antibiotics-come-to-an-end.html

http://www.pbs.org/wgbh/pages/frontline/hunting-the-nightmare-bacteria/
 
http://www.nytimes.com/2013/09/17/health/cdc-report-finds-23000-deaths-a-year-from-antibiotic-resistant-infections.html?_r=0

http://www.cdc.gov/drugresistance/

MRSA
http://www.cdc.gov/MRSA/ 
http://emedicine.medscape.com/article/108972-overview#a1  

Synbody Antibiotic Technology

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0054162
http://www.frontiersin.org/Journal/10.3389/fmicb.2013.00402/full










This project currently has no updates.




Silicon Valley Community Foundation

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Stacy Holmstedt

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Heather Tramel

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Mark Holl

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Carolina Stangherlin

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Patrick Maiella

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Doug Diehnelt

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Renee and Jim Allen

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David May

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Jeff & Carlina Slosky

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Wei Wang

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Avi Shalgi

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Andrey Loskutov

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Laura Britton

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KERL LAJEUNE

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Kelly Rodgers

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Karen Olson

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Christopher Bernard

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Ola Mae Batteau

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Mikayla Madjidi

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Michael & Lauren Madjidi

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Ylli Zhubi

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Dorothy Schroeder

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Carle McFarland

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Nadia Menchaca

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Loretta Colby

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Rebekah Robertson

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Jia-Ming Li

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Janet Kintzle

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Shannon Scarborough

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Michele Hiner

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Nidhi Gupta

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Teresa Gardner

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Pilar Ramos

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Steven Nesbit

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Juliana Park

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Kathy Wimberly

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Bernadine Sadauskas

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Tiffany Antor

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Kerstan Ryan

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Fatjon Leti

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Travis Jacobson

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William Diehnelt

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Lisa Clayton

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Brian Kimball

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Lalaine Cordovez

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Neal Woodbury

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John Lainson

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hu duan

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Lu Wang

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Laura DiPaolo

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Megan Fitzgerald

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Linda Andorka

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Melanie Rue

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Andre Surcouf

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Pattie Madjidi

Gave $100.00

Alexander Carpenter

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Kaitlin Daniels

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Kurt Whittemore

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Luhui Shen

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Matthew Racz

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10 supporters have chosen not to be listed for "New Antibiotics for Superbugs".

Make an Impact

Team Member

Give $25

A $25 contribution helps purchase supplies to support our ongoing research.

Accelerator

Give $100

A $100 contribution helps accelerate the project by supporting undergraduate researchers. Contributors of $100 or more will receive a quarterly update on our research progress.

Leverage

Give $500

A $500 contribution helps secure future support by funding critical proof-of-concept experiments that demonstrate the capabilities of our antibiotic candidates.

Patron

Give $1,000

A $1,000 contribution helps fully support our efforts to build compounds that kill MRSA. Patron level support helps fund collaborations with other MRSA researchers that can rapidly advance our project.